ATF6 and XBP1

Number of citations of the paper that reports this interaction (PubMedID 23661758)
49

Data Source:
BioGRID (fluorescent resonance energy transfer, fluorescent resonance energy transfer)

		ATF6	XBP1
Description		activating transcription factor 6	X-box binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nuclear Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane	Cell Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Eye Development Regulation Of Transcription By RNA Polymerase II Protein Folding Signal Transduction Visual Perception Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Angiogenesis Liver Development Endothelial Cell Proliferation Positive Regulation Of Immunoglobulin Production Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Muscle Organ Development Positive Regulation Of Cell Proliferation Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Protein Transport Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Protein Destabilization Cellular Response To Nutrient Cellular Response To Insulin Stimulus Cellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Positive Regulation Of Immunoglobulin Secretion Fatty Acid Homeostasis Sterol Homeostasis Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Interleukin-6 Secretion
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes
Drugs		Pseudoephedrine
Diseases
GWAS		Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Systemic sclerosis ( 30247649)	Esophageal cancer (squamous cell) ( 22960999) Esophageal squamous cell carcinoma ( 25129146) Heel bone mineral density ( 28869591) Mean arterial pressure ( 29403010) Pancreatic cancer ( 25086665)
Interacting Genes		15 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1	21 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I ZNF440 ZNF580
Entrez ID		22926	7494
HPRD ID		16118	01908
Ensembl ID		ENSG00000118217	ENSG00000100219
Uniprot IDs		A8K383 P18850	A0A024R1F0 P17861
PDB IDs			6R5Q 6R6G 6R6P 6R7Q
Enriched GO Terms of Interacting Partners?
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