XBP1 and HDGF

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		XBP1	HDGF
Description		X-box binding protein 1	heparin binding growth factor
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Transcriptional Repressor Complex Collagen-containing Extracellular Matrix
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity	Nucleotide Binding Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity RNA Binding Growth Factor Activity Heparin Binding
	Biological Process	Angiogenesis Liver Development Endothelial Cell Proliferation Positive Regulation Of Immunoglobulin Production Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Muscle Organ Development Positive Regulation Of Cell Proliferation Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Protein Transport Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Protein Destabilization Cellular Response To Nutrient Cellular Response To Insulin Stimulus Cellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Positive Regulation Of Immunoglobulin Secretion Fatty Acid Homeostasis Sterol Homeostasis Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Interleukin-6 Secretion	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction IRE1-mediated Unfolded Protein Response Cellular Response To Interleukin-7
Pathways			XBP1(S) activates chaperone genes
Drugs			Copper
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999) Esophageal squamous cell carcinoma ( 25129146) Heel bone mineral density ( 28869591) Mean arterial pressure ( 29403010) Pancreatic cancer ( 25086665)	Blood protein levels ( 30072576) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899)
Interacting Genes		21 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I ZNF440 ZNF580	4 interacting genes: APP JUN SMAD4 XBP1
Entrez ID		7494	3068
HPRD ID		01908	02079
Ensembl ID		ENSG00000100219	ENSG00000143321
Uniprot IDs		A0A024R1F0 P17861	A0A384NPW1 A8K8G0 B7Z958 P51858
PDB IDs		6R5Q 6R6G 6R6P 6R7Q	1RI0 2NLU
Enriched GO Terms of Interacting Partners?
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