PLA2R1 and PLA2G10

Number of citations of the paper that reports this interaction (PubMedID 11019817)
18

Data Source:
HPRD (in vivo, in vitro)

		PLA2R1	PLA2G10
Description		phospholipase A2 receptor 1	phospholipase A2 group X
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Carbohydrate Binding Signaling Receptor Activity Phospholipase Binding	Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Cytokine Production Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonic Acid Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Arachidonic Acid Secretion	Phosphatidic Acid Biosynthetic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of DNA-binding Transcription Factor Activity Arachidonic Acid Secretion Lysophospholipid Transport Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux Cellular Response To Leukemia Inhibitory Factor
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs			Varespladib methyl
Diseases
GWAS		Bilirubin levels ( 20639394) Blood protein levels ( 30072576 29875488) Crohn's disease ( 26192919) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 26192919) Membranous nephropathy ( 27333618) Tourette syndrome ( 30818990)	Cholesteryl ester levels ( 31551469) Glycerophospholipid levels ( 26068415)
Interacting Genes		2 interacting genes: PLA2G10 PLA2G2A	2 interacting genes: MYO10 PLA2R1
Entrez ID		22925	8399
HPRD ID		09222	04674
Ensembl ID		ENSG00000153246	ENSG00000069764
Uniprot IDs		B7ZML4 Q13018	O15496
PDB IDs		6JLI	1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?
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