FKBP5 and USP49

Number of citations of the paper that reports this interaction (PubMedID 28363942)
19

Data Source:
BioGRID (enzymatic study)

		FKBP5	USP49
Description		FKBP prolyl isomerase 5	ubiquitin specific peptidase 49
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleoplasm
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Heat Shock Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Histone Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Folding Response To Bacterium Chaperone-mediated Protein Folding	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) ESR-mediated signaling MECP2 regulates neuronal receptors and channels	Ub-specific processing proteases
Drugs
Diseases
GWAS		Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Offspring birth weight ( 31043758) White blood cell count ( 27863252)	Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 23263863 20139978 27863252) Red blood cell count ( 20139978 27863252) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		12 interacting genes: APP CHUK ESR1 FES HSF1 HSP90AA1 IKBKE MAPT NR2C2 PGR STIP1 USP49	9 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 RBCK1 STING1 TP53 TRIM35
Entrez ID		2289	25862
HPRD ID		04019	10075
Ensembl ID		ENSG00000096060	ENSG00000164663
Uniprot IDs		Q13451 Q2TA84	Q70CQ1
PDB IDs		1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM 4R0X 4TW6 4TW7 4TX0 4W9O 4W9P 4W9Q 5BXJ 5DIT 5DIU 5DIV 5NJX 5OBK 5OMP
Enriched GO Terms of Interacting Partners?
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