USP49 and MED18

Number of citations of the paper that reports this interaction (PubMedID 12584197)
20

Data Source:
HPRD (in vitro, in vivo)

		USP49	MED18
Description		ubiquitin specific peptidase 49	mediator complex subunit 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Mediator Complex Core Mediator Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Histone Binding	Transcription Coregulator Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination	Regulation Of Transcription By RNA Polymerase II Termination Of RNA Polymerase II Transcription
Pathways		Ub-specific processing proteases	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 23263863 20139978 27863252) Red blood cell count ( 20139978 27863252) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
Interacting Genes		9 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 RBCK1 STING1 TP53 TRIM35	7 interacting genes: CAMK2B HOMEZ MED20 MED31 MED9 TRIM39 USP49
Entrez ID		25862	54797
HPRD ID		10075	17476
Ensembl ID		ENSG00000164663	ENSG00000130772
Uniprot IDs		Q70CQ1	Q9BUE0
PDB IDs
Enriched GO Terms of Interacting Partners?
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