XRN2 and MOCS3

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRN2	MOCS3
Description		5'-3' exoribonuclease 2	molybdenum cofactor synthesis 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Cytoplasm Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Metal Ion Binding	Thiosulfate Sulfurtransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity Sulfurtransferase Activity URM1 Activating Enzyme Activity Metal Ion Binding Molybdopterin-synthase Sulfurtransferase Activity Molybdopterin-synthase Adenylyltransferase Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	TRNA Wobble Uridine Modification TRNA Wobble Position Uridine Thiolation Mo-molybdopterin Cofactor Biosynthetic Process Enzyme Active Site Formation Via Cysteine Modification To L-cysteine Persulfide Molybdopterin Cofactor Biosynthetic Process Protein Modification By Small Protein Conjugation Protein Urmylation TRNA Thio-modification
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol	Molybdenum cofactor biosynthesis
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		25 interacting genes: ALDH1B1 ATRN COMT CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LSM3 MOCS3 MRPL4 MRPS10 PRAME PSMA3 RAB14 TARDBP TIPARP TOLLIP UPF2	3 interacting genes: EXOSC6 MOCS2 XRN2
Entrez ID		22803	27304
HPRD ID		10309	10092
Ensembl ID		ENSG00000088930	ENSG00000124217
Uniprot IDs		B4DZC3 Q9H0D6	O95396
PDB IDs			3I2V
Enriched GO Terms of Interacting Partners?
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