XRN2 and TIPARP

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		XRN2	TIPARP
Description		5'-3' exoribonuclease 2	TCDD inducible poly(ADP-ribose) polymerase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Nucleus
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Metal Ion Binding	NAD+ ADP-ribosyltransferase Activity Enhancer Binding Metal Ion Binding Protein ADP-ribosylase Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Vasculogenesis Kidney Development Protein ADP-ribosylation Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Negative Regulation Of Gene Expression Hemopoiesis Positive Regulation Of Protein Catabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Roof Of Mouth Development Face Morphogenesis Protein Auto-ADP-ribosylation Cellular Response To Organic Cyclic Compound Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252)	Central corneal thickness ( 29760442) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Chronotype ( 30696823) Epithelial ovarian cancer ( 25581431) Nose size ( 27182965) Ovarian cancer ( 20852632) Testicular germ cell tumor ( 28604732)
Interacting Genes		25 interacting genes: ALDH1B1 ATRN COMT CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LSM3 MOCS3 MRPL4 MRPS10 PRAME PSMA3 RAB14 TARDBP TIPARP TOLLIP UPF2	2 interacting genes: ATM XRN2
Entrez ID		22803	25976
HPRD ID		10309	18192
Ensembl ID		ENSG00000088930	ENSG00000163659
Uniprot IDs		B4DZC3 Q9H0D6	Q05BQ2 Q7Z3E1
PDB IDs
Enriched GO Terms of Interacting Partners?
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