FHL1 and USP15

Number of citations of the paper that reports this interaction (PubMedID 21219870)
3

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FHL1	USP15
Description		four and a half LIM domains 1	ubiquitin specific peptidase 15
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Molecular_function Protein Binding Ion Channel Binding Metal Ion Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Regulation Of Membrane Depolarization Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Protein Deubiquitination BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway
Pathways			Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases		X-linked myopathy with postural muscle atrophy (XMPMA) Reducing body myopathy (RBM) Scapuloperoneal myopathy (SPM) Emery-Dreifuss muscular dystrophy
GWAS			Alopecia areata ( 25608926) Metabolite levels ( 23823483) Plateletcrit ( 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		21 interacting genes: AKAP12 CBX4 CDC25C CHEK2 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE	47 interacting genes: BAP1 BMPR1A BRAP CARD9 CCDC57 DDX58 FHL1 H2BC21 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UBE2S UCHL1 UCHL3 USP14 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		2273	9958
HPRD ID		02157	05293
Ensembl ID		ENSG00000022267	ENSG00000135655
Uniprot IDs		B7Z9A1 Q13642 Q5JXI2	Q9Y4E8
PDB IDs		1X63 2CUP 2CUR 2EGQ	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1
Enriched GO Terms of Interacting Partners?
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