FGD2 and TMEM239

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FGD2	TMEM239
Description		FYVE, RhoGEF and PH domain containing 2	transmembrane protein 239
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium Early Endosome Membrane Ruffle Membrane	Integral Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Metal Ion Binding Phosphatidylinositol Phosphate Binding	Protein Binding
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Medication use (thyroid preparations) ( 31015401) Rosacea symptom severity ( 29771307)	Estimated glomerular filtration rate ( 31451708) Pulse pressure ( 30224653) White matter integrity ( 23218918)
Interacting Genes		2 interacting genes: KLHL12 TMEM239	12 interacting genes: ATF7 COQ8A CXCL16 FGD2 LENG1 MYG1 NTAQ1 POLI S100B SDCBP SENP2 USP5
Entrez ID		221472	100288797
HPRD ID		05478
Ensembl ID		ENSG00000146192	ENSG00000198326
Uniprot IDs		Q7Z6J4	Q8WW34
PDB IDs
Enriched GO Terms of Interacting Partners?
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