EYA2 and AATK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		EYA2	AATK
Description		EYA transcriptional coactivator and phosphatase 2	apoptosis associated tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol	Cellular_component Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	DNA Repair Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Biological_process Peptidyl-tyrosine Phosphorylation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Allergic rhinitis ( 31361310) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Lung function (FVC) ( 30061609 30804560) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Neuroticism ( 29255261) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		9 interacting genes: AATK DMRTB1 GNAI2 GNAZ LOX RBPMS ROR2 SIX1 SIX4	40 interacting genes: CDC14A CDC25B CDK5 DUPD1 DUSP1 DUSP14 DUSP5 DUSP6 DUSP9 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP1CB PPP1CC PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TPTE2
Entrez ID		2139	9625
HPRD ID		09041	05591
Ensembl ID		ENSG00000064655	ENSG00000181409
Uniprot IDs		E7ETN2 O00167	H7C175 Q6ZMQ8
PDB IDs		3GEB 3HB0 3HB1 4EGC 5ZMA
Enriched GO Terms of Interacting Partners?
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