ESR2 and KAT5

Number of citations of the paper that reports this interaction (PubMedID 11591700)
26

Data Source:
BioGRID (two hybrid)

		ESR2	KAT5
Description		estrogen receptor 2	lysine acetyltransferase 5
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion	Histone Acetyltransferase Complex Nuclear Chromatin Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding Estrogen Receptor Activity Estrogen Response Element Binding Identical Protein Binding Receptor Antagonist Activity	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity Acetyltransferase Activity Histone Binding Metal Ion Binding Androgen Receptor Binding Peptide-lysine-N-acetyltransferase Activity Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Growth Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Signaling Receptor Activity	Negative Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing DNA Replication Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Positive Regulation Of Autophagy Viral Process Histone Acetylation Peptidyl-lysine Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Acetylation Beta-catenin-TCF Complex Assembly
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ESR-mediated signaling Extra-nuclear estrogen signaling	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression
Drugs		Diethylstilbestrol Raloxifene Estrone Tamoxifen Estradiol Trilostane Estramustine Oxybenzone Genistein Prasterone Benzophenone Phthalic Acid Pyrazole Para-Mercury-Benzenesulfonic Acid Naringenin N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide 5-Alpha-Androstane-3-Beta,17beta-Diol 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Quercetin Afimoxifene Estriol Estrone sulfate MF101 CHF 4227 Lasofoxifene Bazedoxifene 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one Erteberel (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL Eugenol Octocrylene Enzacamene Equol 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol	Coenzyme A S-Acetyl-Cysteine
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 30061737) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Metabolite levels ( 23823483) Prostate cancer ( 26443449) Red blood cell count ( 27863252)	Acne (severe) ( 24927181) Asthma ( 31619474) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 30598549) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglycerides ( 30275531)
Interacting Genes		98 interacting genes: AGR3 AKAP13 AKT1 ARID5A BCAS2 CALM1 CALM2 CALM3 CASC3 CASZ1 CCNC CDK8 DAP3 DDX54 DKK3 DNMT3L DNTTIP2 EP300 ESR1 IL13RA2 IL24 ITIH5 JMJD1C KAT5 KLK9 LCK LRATD2 MAD2L1 MAPK1 MAPK11 MED1 MED10 MED12 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED6 MED7 MEOX2 MKNK2 MMS19 MRC2 MSH2 NCOA1 NCOA2 NCOA3 NCOA6 NCOA7 NCOR1 NCOR2 NFKBIB NOTCH2NLA NR0B1 NR0B2 NRIP1 OXT PELP1 PIAS1 PIAS2 PIAS3 PLSCR1 PNRC1 PNRC2 PPARGC1A PPP5C PRMT2 PRSS50 PSMC3IP PSMC5 RBFOX2 RBM39 REXO4 RFX6 SERPINH1 SMAD2 SMAD3 SMAD4 SMARCE1 SP1 SRA1 SRC SREBF1 STAT5A TFF1 TRAM1 TRIM24 TRIM59 TRIP4 TXNRD1 WIPI1 YWHAH YWHAQ ZBTB17 ZNHIT3	144 interacting genes: AGO2 ALOX12 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DNAAF6 DUSP23 E2F1 EDNRA EFNA1 EP300 EP400 ESR1 ESR2 ETV6 FAM135B GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL2 GOLGA2 GSTO1 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4-16 H4C1 H4C14 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 IK IKZF3 IL9R KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PFKP PHC2 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SRSF2 SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YIF1A YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513
Entrez ID		2100	10524
HPRD ID		03390	03245
Ensembl ID		ENSG00000140009	ENSG00000172977
Uniprot IDs		A0A348FV93 F1D8N3 Q0PTK2 Q7LCB3 Q92731	A0A024R597 A0A024R5E8 Q92993
PDB IDs		1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26 4ZI1 5TOA	2EKO 2OU2 4QQG
Enriched GO Terms of Interacting Partners?
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