EPS8 and ABI1

Number of citations of the paper that reports this interaction (PubMedID 10499589)
114

Data Source:
HPRD (in vitro, in vivo)

		EPS8	ABI1
Description		epidermal growth factor receptor pathway substrate 8	abl interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Cell Cortex Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Stereocilium Tip Ruffle Membrane Extracellular Exosome Glutamatergic Synapse	Intracellular Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Aggresome Lamellipodium Cell Junction Growth Cone SCAR Complex Filopodium Tip Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Signaling Adaptor Activity Rac GTPase Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Cadherin Binding
	Biological Process	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor	Somitogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Proliferation Viral Process Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3	29 interacting genes: ABL1 APBB1 CACNA1A CUL2 CYFIP2 ENAH EPS8 EPS8L1 EVL GAS7 HSPA8 MINK1 NCK1 NCK2 NCKAP1 NEB NIN PAK2 PCM1 PRPF40A SOS1 SOS2 SPTA1 SPTAN1 SRRM1 TCERG1 VASP WASF1 WASF2
Entrez ID		2059	10006
HPRD ID		02563	04336
Ensembl ID		ENSG00000151491	ENSG00000136754
Uniprot IDs		B4E3T6 Q12929	A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0
PDB IDs		2E8M
Enriched GO Terms of Interacting Partners?
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