CLN8 and STX8

Number of citations of the paper that reports this interaction (PubMedID 23142642)
4

Data Source:
BioGRID (two hybrid)

		CLN8	STX8
Description		CLN8 transmembrane ER and ERGIC protein	syntaxin 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Integral Component Of Plasma Membrane Endomembrane System Integral Component Of Membrane SNARE Complex Late Endosome Membrane Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding Ceramide Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Nervous System Development Cholesterol Metabolic Process Lipid Biosynthetic Process Protein Catabolic Process Negative Regulation Of Proteolysis Ceramide Biosynthetic Process	Intracellular Protein Transport Vesicle Fusion Endosome To Lysosome Transport Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Interferon-gamma Regulation Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
Interacting Genes		29 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUP1	18 interacting genes: ACVR1 AQP2 CALM1 CLN8 COPA CREB3 LMNA NAPA NAPG NSF STX1A STX4 STX7 TGFBR1 VPS11 VPS18 VTI1B WDR91
Entrez ID		2055	9482
HPRD ID		06383	05012
Ensembl ID		ENSG00000182372	ENSG00000170310
Uniprot IDs		A0A024QZ57 Q9UBY8	Q9UNK0
PDB IDs
Enriched GO Terms of Interacting Partners?
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