ENO1 and SERPING1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ENO1	SERPING1
Description		enolase 1	serpin family G member 1
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GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane M Band Extracellular Exosome Cell Cortex Region	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Protein Homodimerization Activity Cadherin Binding GTPase Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response
Pathways		Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Regulation of Complement cascade
Drugs		Zinc Copper Artenimol	C1-INH Copper
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Plateletcrit ( 27863252) Tonsillectomy ( 27182965 28928442) White blood cell count (basophil) ( 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488 28240269) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		26 interacting genes: AGTPBP1 AMBP BHLHE40 BRCA1 CHEK2 CLK1 FANCA FYN GRB2 HDAC1 HEMGN HSPB2 LIG4 MCPH1 MYOC PCNA PLG SERPING1 SRC SUMO2 SUMO4 TERT TRAPPC2 UPF2 YWHAQ YWHAZ	15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		2023	710
HPRD ID		01400	06033
Ensembl ID		ENSG00000074800	ENSG00000149131
Uniprot IDs		A0A024R4F1 P06733	E9KL26 P05155
PDB IDs		2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK	1M6Q 2OAY 5DU3 5DUQ
Enriched GO Terms of Interacting Partners?
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