ELF3 and XRCC6

Number of citations of the paper that reports this interaction (PubMedID 15075319)
15

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ELF3	XRCC6
Description		E74 like ETS transcription factor 3	X-ray repair cross complementing 6
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Extracellular Region Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding	DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding Cyclin Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Protein-containing Complex Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Blastocyst Development Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Multicellular Organism Development Epidermis Development Cell Differentiation Extracellular Matrix Organization Epithelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mammary Gland Involution	Telomere Maintenance Activation Of Innate Immune Response DNA Ligation Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Brain Development Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Neutrophil Degranulation Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Pre-NOTCH Transcription and Translation	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs
Diseases
GWAS			Breast cancer ( 29059683) Neuroticism ( 29255261) Pulse pressure ( 28135244)
Interacting Genes		15 interacting genes: AR CREBBP EGFR EP300 EPS15 JUN MED23 MYC NFKB1 PAK1 SOX9 TAF9 TBP XRCC5 XRCC6	131 interacting genes: ABCD4 ABL1 ACD ADCY7 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 ETS1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HERPUD1 HMGA2 HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TOP1 TP53 UBC VAV1 VBP1 WBP4 WRN XRCC5 YWHAZ ZBTB7A ZNF512B
Entrez ID		1999	2547
HPRD ID		03722	01071
Ensembl ID		ENSG00000163435	ENSG00000196419
Uniprot IDs		A0A024R974 P78545	A0A024R1N4 B1AHC9 B4DE32 B4E356 P12956
PDB IDs		2E8P	1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH
Enriched GO Terms of Interacting Partners?
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