AP2M1 and LAMP1

Number of citations of the paper that reports this interaction (PubMedID 7569928)
331

Data Source:
HPRD (two hybrid, in vitro)

		AP2M1	LAMP1
Description		adaptor related protein complex 2 subunit mu 1	lysosomal associated membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Extracellular Exosome	Cytoplasm Lysosome Lysosomal Membrane Late Endosome Multivesicular Body Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Integral Component Of Synaptic Vesicle Membrane Dendrite Late Endosome Membrane Azurophil Granule Membrane Sarcolemma Melanosome Neuronal Cell Body Cytolytic Granule Autolysosome Perinuclear Region Of Cytoplasm Phagolysosome Membrane Extracellular Exosome Alveolar Lamellar Body Ficolin-1-rich Granule Membrane
	Molecular Function	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Ion Channel Binding Low-density Lipoprotein Particle Receptor Binding	Virus Receptor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding
	Biological Process	Intracellular Protein Transport Vesicle Budding From Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Cellular Protein-containing Complex Assembly Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Regulation Of Vesicle Size Negative Regulation Of Protein Localization To Plasma Membrane	Granzyme-mediated Apoptotic Signaling Pathway Neutrophil Degranulation Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Viral Entry Into Host Cell Autophagic Cell Death Protein Stabilization Establishment Of Protein Localization To Organelle Golgi To Lysosome Transport Regulation Of Organelle Transport Along Microtubule
Pathways		Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance	Neutrophil degranulation
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Bipolar disorder ( 31043756)
Interacting Genes		51 interacting genes: ADRA1B AP2B1 AQP4 ARRB2 ATXN1L CACNA1A CD22 CD3D CDK11B CKS1B CORO7 CRIP1 CSNK2B CTLA4 DAB2 DCX DNAJB11 DPPA2 DVL2 EHD2 EIF4G1 ETV5 FGF12 FURIN FXR2 GAK GRIN2B IKZF1 IL1RAP JADE1 KCNJ11 LAMP1 LPP LY9 MED4 MEGF10 NCOR2 NDRG1 RALBP1 RPL38 RRP12 RSPH14 RUNDC3A STON2 SYNJ1 TASOR TBC1D5 TGOLN2 UBC XPA ZBTB8A	2 interacting genes: AP1M1 AP2M1
Entrez ID		1173	3916
HPRD ID		03014	01076
Ensembl ID		ENSG00000161203	ENSG00000185896
Uniprot IDs		B4DNB9 E9PFW3 Q96CW1	A0A024RDY3 P11279
PDB IDs		1H6E 6BNT
Enriched GO Terms of Interacting Partners?
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