MLKL and ANAPC11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MLKL	ANAPC11
Description		mixed lineage kinase domain like pseudokinase	anaphase promoting complex subunit 11
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding	Ubiquitin-protein Transferase Activity Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Protein Homotrimerization Necroptotic Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		TRP channels RIPK1-mediated regulated necrosis	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Interacting Genes		5 interacting genes: ANAPC11 CDK1 NDUFB7 RAD18 THOC3	26 interacting genes: ANAPC10 ANAPC2 ANAPC4 CAPN11 CCNB1 CDC16 CDC20 CUL5 FBXO5 FZR1 MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U ZAP70
Entrez ID		197259	51529
HPRD ID		08752	12452
Ensembl ID		ENSG00000168404	ENSG00000141552
Uniprot IDs		Q8NB16	A0A024R8S1 A0A087X1B5 Q9NYG5
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74	2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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