EHHADH and CAT

Number of citations of the paper that reports this interaction (PubMedID 29568061)
14

Data Source:
BioGRID (proximity labelling technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)

		EHHADH	CAT
Description		enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	catalase
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Dodecenoyl-CoA Delta-isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Enzyme Binding	Peroxisome Targeting Sequence Binding Aminoacylase Activity Catalase Activity Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding
	Biological Process	Internal Protein Amino Acid Acetylation Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Protein Targeting To Peroxisome Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Response To Inactivity Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Cellular Response To Oxidative Stress Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Response To Ethanol Response To Cadmium Ion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Response To Hyperoxia Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Phenylpropanoid Cellular Oxidant Detoxification
Pathways		Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import	Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		NADH	Fomepizole
Diseases			Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS		Cognitive performance ( 19734545) Major depressive disorder ( 27519822 21042317)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		27 interacting genes: ACTB ACTG1 BHLHE40 CAT CBS CCDC102B DES FUNDC1 KCTD6 KCTD9 KRTAP10-7 LZTS2 MID1 NECAB2 PNMA1 SCP2 SSNA1 SSX2IP TNIP1 TPP2 TRAF1 TRIM27 TRIM41 TRIM54 TRIM55 TRIM63 ZBTB9	8 interacting genes: ABL1 ABL2 APP EHHADH KEAP1 PTPN11 SUMO4 TLR10
Entrez ID		1962	847
HPRD ID		06125	00282
Ensembl ID		ENSG00000113790	ENSG00000121691
Uniprot IDs		Q08426	A0A384P5Q0 P04040
PDB IDs			1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
Enriched GO Terms of Interacting Partners?
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