EGR2 and PDE4DIP

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		EGR2	PDE4DIP
Description		early growth response 2	phosphodiesterase 4D interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Golgi Apparatus Centrosome Myofibril
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding SUMO Ligase Activity HMG Box Domain Binding	Protein Binding Enzyme Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Export From Nucleus Brain Development Peripheral Nervous System Development Learning Or Memory Rhythmic Behavior Motor Neuron Axon Guidance Schwann Cell Differentiation Protein Sumoylation Facial Nerve Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Regulation Of Ossification Response To Insulin Brain Segmentation Skeletal Muscle Cell Differentiation Myelination Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neuronal Synaptic Plasticity Cellular Response To Organic Substance	Cellular Protein-containing Complex Assembly Regulation Of Golgi Organization
Pathways		Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Adventurousness ( 30643258) Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Ewing sarcoma ( 22327514) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Selective IgA deficiency ( 27723758) Temperament ( 22832960) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Vogt-Koyanagi-Harada syndrome ( 25108386)	Capecitabine sensitivity ( 22864933)
Interacting Genes		19 interacting genes: ACP5 BPGM DNMT3L GOLGA2 HCFC1 JPT2 MED31 NAB2 NDUFS2 NFATC1 PDE4DIP RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WWP2	76 interacting genes: ADH1B AEN ANKRD11 ARNT2 BYSL C1orf109 CCDC146 CCDC198 CDC5L CDKN1A CHCHD3 CHD1L EGR2 EIF4E2 FAM161A FAM74A4 FCHSD2 FES FHL1 GADD45G GBE1 GFI1B GNRHR2 GOLGA5 GOLGA8EP GOLGA8F HAUS1 IMMT ITSN2 KDM1A KLC3 KLC4 KRAS KRT1 KRT18 KRT31 LAMTOR3 LENG1 LMO4 MIF4GD MTUS2 NAA10 NEFL NEK2 OSGEP PDE4D PEA15 PFDN1 PIAS4 PPP1R18 PRNP PRPF31 RBM8A RTP5 SCNM1 SDCBP SH2D4A SHFL SMN1 SNCA TEAD4 TFIP11 THRB TK1 TMOD4 TNIK TRAF4 UTP14C VAC14 ZBTB38 ZDHHC17 ZFYVE21 ZNF408 ZNF512B ZNF581 ZSCAN26
Entrez ID		1959	9659
HPRD ID		00551	10482
Ensembl ID		ENSG00000122877	ENSG00000178104
Uniprot IDs		P11161	A0A075B749 A0A087WYE4 Q5VU43
PDB IDs
Enriched GO Terms of Interacting Partners?
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