PHC1 and SFMBT1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		PHC1	SFMBT1
Description		polyhomeotic homolog 1	Scm like with four mbt domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Transcription Corepressor Activity Protein Binding Histone Binding
	Biological Process	Multicellular Organism Development Histone Ubiquitination Negative Regulation Of G0 To G1 Transition	Chromatin Organization Spermatogenesis Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Muscle Organ Development
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Estimated glomerular filtration rate ( 31152163 29124443) General cognitive ability ( 29844566) Gout ( 31578528) Hand grip strength ( 29691431) Height ( 28552196 31562340 31217584) Hip circumference ( 28552196) Hyperuricemia ( 29124443) Intelligence (MTAG) ( 29326435) Mental health study participation (completed survey) ( 31263887) Multiple sclerosis ( 31604244) Schizophrenia ( 28991256 23974872) Serum uric acid levels ( 30993211 29124443 29403010) Type 2 diabetes (age of onset) ( 28060188) Urate levels ( 31578528 23263486)
Interacting Genes		17 interacting genes: BMI1 GMNN HSPA8 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 SCMH1 SFMBT1 SIAH1 SP100 SUMO1 SUMO1P1 UBE2I ZCCHC7	7 interacting genes: ACP1 CLNK PHC1 PHC2 PSMA1 SRPK1 ZCCHC10
Entrez ID		1911	51460
HPRD ID		16009	09539
Ensembl ID		ENSG00000111752	ENSG00000163935
Uniprot IDs		P78364 Q6GMQ3 Q6N083	A0A024R338 Q9UHJ3
PDB IDs		2L8E
Enriched GO Terms of Interacting Partners?
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