E2F5 and RBL1

Number of citations of the paper that reports this interaction (PubMedID 7892279)
98

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		E2F5	RBL1
Description		E2F transcription factor 5	RB transcriptional corepressor like 1
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GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex	Chromatin Nucleoplasm Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Bacterial-type RNA Polymerase Transcriptional Activator Activity, Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity	RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Cell Projection Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Viral Process Cell Differentiation Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)	Height ( 25429064) Red cell distribution width ( 28957414)
Interacting Genes		8 interacting genes: CREBBP DNMT3L EP300 RBL1 RBL2 SMAD3 TFDP1 XPO1	54 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4
Entrez ID		1875	5933
HPRD ID		02983	00312
Ensembl ID		ENSG00000133740	ENSG00000080839
Uniprot IDs		Q15329	P28749
PDB IDs		5TUV	1H28 4YOO 4YOS 4YOZ 5TUV
Enriched GO Terms of Interacting Partners?
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