DSC3 and JUP

Number of citations of the paper that reports this interaction (PubMedID 10769211)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DSC3	JUP
Description		desmocollin 3	junction plakoglobin
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Integral Component Of Membrane Cell Junction Desmosome	Cornified Envelope Extracellular Region Cell Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Calcium Ion Binding Gamma-catenin Binding	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Cornification Cell-cell Adhesion	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cytoskeletal Anchoring At Plasma Membrane Cell Migration Keratinization Adherens Junction Organization Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Cornification Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Keratinization Formation of the cornified envelope	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc
Diseases		Hypotrichosis and recurrent skin vesicles	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome
GWAS		Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 31628463) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Supraventricular ectopy ( 29618737) Type 2 diabetes ( 31049640)	Heel bone mineral density ( 30598549 28869591)
Interacting Genes		6 interacting genes: CTNNB1 DDX10 JUP PKP3 PKP4 UCHL5	47 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNBIP1 CTNND1 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 FER FHL2 FYN MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 SRC TBP TCF4 TCF7L2 ZFYVE9
Entrez ID		1825	3728
HPRD ID		02604	01414
Ensembl ID		ENSG00000134762	ENSG00000173801
Uniprot IDs		Q14574	A0A0S2Z487 P14923
PDB IDs			3IFQ
Enriched GO Terms of Interacting Partners?
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