DRD3 and CLIC6

Number of citations of the paper that reports this interaction (PubMedID 14499480)
16

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DRD3	CLIC6
Description		dopamine receptor D3	chloride intracellular channel 6
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Synaptic Vesicle Membrane Cell Projection Apical Part Of Cell Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Density Membrane	Cytoplasm Plasma Membrane Chloride Channel Complex Extracellular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Adrenergic Receptor Activity Protein Binding Drug Binding Protein Domain Specific Binding D1 Dopamine Receptor Binding Dopamine Binding	Voltage-gated Ion Channel Activity Chloride Channel Activity D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Blood Volume By Renin-angiotensin G Protein-coupled Receptor Internalization Cellular Calcium Ion Homeostasis Autophagy G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Cell-cell Signaling Behavior Learning Or Memory Learning Locomotory Behavior Positive Regulation Of Cell Proliferation Visual Learning Response To Toxic Substance Regulation Of Dopamine Secretion Regulation Of Lipid Metabolic Process Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Gastric Emptying Positive Regulation Of Renal Sodium Excretion Regulation Of Multicellular Organism Growth Response To Cocaine Dopamine Metabolic Process Response To Drug Negative Regulation Of Apoptotic Process Regulation Of Potassium Ion Transport Response To Morphine Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Acid Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Negative Regulation Of Oligodendrocyte Differentiation Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Voltage-gated Calcium Channel Activity	Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Dopamine receptors G alpha (i) signalling events
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Mirtazapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Haloperidol Amoxapine Lisuride Apomorphine Risperidone Dopamine Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine ACP-104 Cariprazine Mianserin Asenapine Amisulpride Captodiame AS-8112 Pardoprunox Piribedil Tiapride
Diseases
GWAS		Chronotype ( 30696823) Feeling hurt ( 29500382) Personality dimensions ( 23903073) Smooth-surface caries ( 24556642)	Breast cancer ( 31757997) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hippocampal volume ( 29274321) Psoriasis ( 25903422) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		16 interacting genes: CLIC6 DRD1 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX USP48	3 interacting genes: DRD2 DRD3 DRD4
Entrez ID		1814	54102
HPRD ID		00540	10836
Ensembl ID		ENSG00000151577	ENSG00000159212
Uniprot IDs		A1A4V4 A8K8E4 E9PCM4 P35462 X5D2G4	Q96NY7
PDB IDs		3PBL
Enriched GO Terms of Interacting Partners?
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