DRD1 and HRH3

Number of citations of the paper that reports this interaction (PubMedID 19413572)
42

Data Source:
BioGRID (fluorescent resonance energy transfer)

		DRD1	HRH3
Description		dopamine receptor D1	histamine receptor H3
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Junction Dendritic Spine Ciliary Membrane Non-motile Cilium Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Presynapse
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Adrenergic Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Synapse Assembly Behavior Memory Mating Behavior Grooming Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Gene Expression Astrocyte Development Dopamine Transport Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Operant Conditioning Regulation Of Dopamine Metabolic Process Vasodilation Dopamine Metabolic Process Response To Drug Maternal Behavior Positive Regulation Of Potassium Ion Transport Histone H3-S10 Phosphorylation Glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cellular Response To Dopamine Regulation Of Synaptic Vesicle Exocytosis	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Neurotransmitter Secretion Negative Regulation Of Glutamate Secretion Regulation Of Norepinephrine Secretion Negative Regulation Of Serotonin Secretion Cognition G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Histamine receptors G alpha (i) signalling events
Drugs		Ziprasidone Cabergoline Cabergoline Ropinirole Olanzapine Olanzapine Methylergometrine Clozapine Mirtazapine Thiethylperazine Phenylpropanolamine Loxapine Loxapine Pramipexole Promazine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Mianserin Asenapine Quinagolide Tetrahydropalmatine Dihydrexidine	Mirtazapine OBE101 Histamine Betahistine
Diseases
GWAS		Cadmium levels ( 26025379) Chin dimples ( 27182965) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Prostate cancer ( 23535732)
Interacting Genes		14 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 PRKACA	1 interacting genes: DRD1
Entrez ID		1812	11255
HPRD ID		00538	05162
Ensembl ID		ENSG00000184845	ENSG00000101180
Uniprot IDs		P21728	Q9Y5N1
PDB IDs		1OZ5
Enriched GO Terms of Interacting Partners?
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