HRH3 and DRD1

Number of citations of the paper that reports this interaction (PubMedID 19413572)
42

Data Source:
BioGRID (fluorescent resonance energy transfer)

		HRH3	DRD1
Description		histamine receptor H3	dopamine receptor D1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Presynapse	Cell Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Junction Dendritic Spine Ciliary Membrane Non-motile Cilium Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Adrenergic Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Neurotransmitter Secretion Negative Regulation Of Glutamate Secretion Regulation Of Norepinephrine Secretion Negative Regulation Of Serotonin Secretion Cognition G Protein-coupled Serotonin Receptor Signaling Pathway	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Synapse Assembly Behavior Memory Mating Behavior Grooming Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Gene Expression Astrocyte Development Dopamine Transport Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Operant Conditioning Regulation Of Dopamine Metabolic Process Vasodilation Dopamine Metabolic Process Response To Drug Maternal Behavior Positive Regulation Of Potassium Ion Transport Histone H3-S10 Phosphorylation Glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cellular Response To Dopamine Regulation Of Synaptic Vesicle Exocytosis
Pathways		Histamine receptors G alpha (i) signalling events	Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Mirtazapine OBE101 Histamine Betahistine	Ziprasidone Cabergoline Cabergoline Ropinirole Olanzapine Olanzapine Methylergometrine Clozapine Mirtazapine Thiethylperazine Phenylpropanolamine Loxapine Loxapine Pramipexole Promazine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Mianserin Asenapine Quinagolide Tetrahydropalmatine Dihydrexidine
Diseases
GWAS		Prostate cancer ( 23535732)	Cadmium levels ( 26025379) Chin dimples ( 27182965) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		1 interacting genes: DRD1	14 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 PRKACA
Entrez ID		11255	1812
HPRD ID		05162	00538
Ensembl ID		ENSG00000101180	ENSG00000184845
Uniprot IDs		Q9Y5N1	P21728
PDB IDs			1OZ5
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?