DPYSL3 and TNIK

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		DPYSL3	TNIK
Description		dihydropyrimidinase like 3	TRAF2 and NCK interacting kinase
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol Lamellipodium Growth Cone Filamentous Actin Cell Body Synapse Exocytic Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides SH3 Domain Binding Filamin Binding Chondroitin Sulfate Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Neuron Development Response To Axon Injury Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Actin Crosslink Formation Cellular Response To Cytokine Stimulus	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Signal Transduction By Protein Phosphorylation Microvillus Assembly Stress-activated Protein Kinase Signaling Cascade Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Intracellular Signal Transduction Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		CRMPs in Sema3A signaling	Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS		Excessive daytime sleepiness ( 27992416) Metabolite levels ( 23823483)	Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 27863252) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Type 2 diabetes ( 30054458)
Interacting Genes		7 interacting genes: ACD DISC1 DPYSL5 HYOU1 POT1 TERF1 TNIK	37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		1809	23043
HPRD ID		03104	18206
Ensembl ID		ENSG00000113657	ENSG00000154310
Uniprot IDs		A0A140VK07 Q14195 Q6DEN2 Q8IXW6	Q9UKE5
PDB IDs		4BKN 4CNS 4CNT 4CNU	2X7F 5AX9 5CWZ 5D7A 6RA7
Enriched GO Terms of Interacting Partners?
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