AGER and S100B

Number of citations of the paper that reports this interaction (PubMedID 10399917)
481

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		AGER	S100B
Description		advanced glycosylation end-product specific receptor	S100 calcium binding protein B
Image
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Cell Junction Postsynapse	Ruffle Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding S100 Protein Binding Protein-containing Complex Binding Advanced Glycation End-product Receptor Activity	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Response To Hypoxia Microglial Cell Activation Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Protein Phosphorylation Endocytosis Inflammatory Response Cell Surface Receptor Signaling Pathway Learning Or Memory Response To Wounding Glucose Mediated Signaling Pathway Neuron Projection Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of JUN Kinase Activity Transcytosis Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Synaptic Plasticity Positive Regulation Of Interleukin-1 Beta Biosynthetic Process Induction Of Positive Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA Binding Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotactic Protein-1 Production Protein Localization To Membrane Modulation Of Age-related Behavioral Decline Regulation Of Spontaneous Synaptic Transmission Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Regulation Of P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Circulation Positive Regulation Of Endothelin Secretion Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Response To Amyloid-beta Cellular Response To Amyloid-beta Positive Regulation Of Monocyte Extravasation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Dendritic Cell Differentiation	Axonogenesis Central Nervous System Development Learning Or Memory Memory Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways		TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Nuclear signaling by ERBB4 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs			Olopatadine Calcium N-Formylmethionine Arundic acid (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Calcium Citrate Calcium Phosphate
Diseases
GWAS		Advanced glycation end-product levels ( 26083729) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Blood protein levels in cardiovascular risk ( 28369058) Chronic obstructive pulmonary disease ( 28166215 30804561) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Percentage gas trapping ( 26030696) Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Response to Pazopanib in cancer (hepatotoxicity) ( 26546620) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Ulcerative colitis ( 28067908)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Lymphocyte counts ( 22286170)
Interacting Genes		8 interacting genes: APP CREB3 HMGB1 S100A1 S100A12 S100B S100P TTR	42 interacting genes: ADTRP AGER AGTRAP AHNAK ANXA6 BCL2L2 CACYBP CALM1 CAPZA1 CEP20 CT45A5 DES DNAJC30 FBXO7 FBXW5 GFAP GUCY2D IMP4 IMPA1 IQGAP1 MAL2 MAPT MDM2 MDM4 NDRG1 NKAPD1 PCNT PGM1 RABAC1 S100A1 S100A11 S100A2 S100A6 S100P SPG21 STK38 SUGT1 TMEM159 TMEM239 TNIP1 TP53 VAV1
Entrez ID		177	6285
HPRD ID		02568	01505
Ensembl ID		ENSG00000204305	ENSG00000160307
Uniprot IDs		A0A1U9X785 B4DNX3 Q15109	A0A0S2Z4C5 P04271
PDB IDs		1PWI 2BJP 2E5E 2ENS 2L7U 2LE9 2LMB 2M1K 2MJW 2MOV 3CJJ 3O3U 4LP4 4LP5 4OF5 4OFV 4OI7 4OI8 4P2Y 4XYN 4YBH 5D7F	1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM 4XYN 5CSF 5CSI 5CSJ 5CSN 5D7F
Enriched GO Terms of Interacting Partners?
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