DDIT3 and JUND

Number of citations of the paper that reports this interaction (PubMedID 10523647)
40

Data Source:
HPRD (in vitro, in vivo)

		DDIT3	JUND
Description		DNA damage inducible transcript 3	JunD proto-oncogene, AP-1 transcription factor subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Late Endosome Cytosol Protein-DNA Complex CHOP-C/EBP Complex CHOP-ATF4 Complex CHOP-ATF3 Complex	Chromatin Nuclear Chromatin Nucleoplasm Transcription Factor Complex Protein-DNA Complex Transcription Factor AP-1 Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Transcription Factor Binding Nuclear Receptor Binding Enzyme Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Maturation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus ER Overload Response Response To Unfolded Protein Cell Cycle Arrest Regulation Of Autophagy Wnt Signaling Pathway Positive Regulation Of Interleukin-8 Production Negative Regulation Of CREB Transcription Factor Activity Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Response To Starvation MRNA Transcription By RNA Polymerase II Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription Involved In Anterior/posterior Axis Specification Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Development Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Aging Circadian Rhythm Response To Radiation Response To Light Stimulus Response To Mechanical Stimulus Response To Organic Substance Response To Lipopolysaccharide Cellular Response To Hormone Stimulus Cellular Response To Stress Response To Cytokine Regulation Of Cell Proliferation Response To Drug Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To CAMP Regulation Of Cell Cycle Cellular Response To Calcium Ion
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Estrogen-dependent gene expression NGF-stimulated transcription
Drugs
Diseases		Myxoid liposarcoma
GWAS			Bronchodilator response in asthma ( 25562107) Estimated glomerular filtration rate ( 31015462 30604766) Hand grip strength ( 29691431) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count (monocyte) ( 28158719)
Interacting Genes		61 interacting genes: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 CCDC153 CDK6 CEBPA CEBPB CEBPE CEBPG CREB3 CREB3L1 CSNK2A1 DBP DGCR2 DNMT3L EMSY EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JUN JUNB JUND KPNA2 LMO2 MAFF MAFG MAPK14 MCMBP NFIL3 PCM1 PICALM POLR1D RAI1 RPS3 RPS3A SNAPC5 SPOP SRA1 SSX3 TEDC1 TNFSF12 TRIB3 VPS37C ZBTB25 ZC3H14 ZSCAN31	30 interacting genes: ACTR3 ATF3 BATF BCL6 BRCA1 CCND1 COP1 COPS5 DDIT3 EP300 ESR1 FOS FOSB FOSL2 HINFP JDP2 LINC00461 MAPK1 MAPK3 MAPK8 MAPK9 MDM2 MEN1 NFE2L1 NFE2L2 PPARG SLC25A12 SMAD3 SMAD4 TBP
Entrez ID		1649	3727
HPRD ID		00529	01304
Ensembl ID		ENSG00000175197	ENSG00000130522
Uniprot IDs		P35638 Q53YD1	P17535
PDB IDs			3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF
Enriched GO Terms of Interacting Partners?
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