CCDC116 and BEX3

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		CCDC116	BEX3
Description		coiled-coil domain containing 116	brain expressed X-linked 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome	Nucleus Cytosol
	Molecular Function	Protein Binding	Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding
	Biological Process		Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organism Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways			NADE modulates death signalling
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Ulcerative colitis ( 28067908)
Interacting Genes		11 interacting genes: BEX3 CCDC85B CEP44 FAM9B KRTAP4-12 MDFI MTUS2 SLC2A4 TFIP11 TRAF1 USHBP1	29 interacting genes: AIMP2 AKAP8L CACYBP CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 FSD2 GOLGA8EP GOLGA8F MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 SIVA1 SMPD1 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSC1 USHBP1 VTA1 YWHAE
Entrez ID		164592	27018
HPRD ID		08203	02291
Ensembl ID		ENSG00000161180	ENSG00000166681
Uniprot IDs		Q8IYX3	Q00994
PDB IDs			1SA6
Enriched GO Terms of Interacting Partners?
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