SPRED1 and OSGEP

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		SPRED1	OSGEP
Description		sprouty related EVH1 domain containing 1	O-sialoglycoprotein endopeptidase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Caveola Cytoplasmic Vesicle	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Speck
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Binding Metal Ion Binding N(6)-L-threonylcarbamoyladenine Synthase Activity
	Biological Process	MAPK Cascade Inactivation Of MAPK Activity Negative Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Phosphatase Activity Negative Regulation Of Angiogenesis Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Deacetylation	TRNA Threonylcarbamoyladenosine Modification
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants	tRNA modification in the nucleus and cytosol
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Bipolar disorder ( 20351715) Birth weight ( 31043758) Cognitive performance (processing speed) ( 31598132) Crohn's disease ( 23128233) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)	Food addiction ( 27106561)
Interacting Genes		11 interacting genes: CDKN1A DNAJB11 FAM118B KIT NAGK OSGEP PPP1CA RCC1 SUV39H1 TSC22D1 TTC19	23 interacting genes: CIAPIN1 CRIP2 EMCN GP1BA HPS6 LENG1 MUC1 NR3C1 NVL OPTC PDE4DIP PKP4 RBM48 REX1BD SF3B3 SHC1 SP110 SPRED1 TNS1 WDR82 WIZ ZNF579 ZNF775
Entrez ID		161742	55644
HPRD ID		11601	10133
Ensembl ID		ENSG00000166068	ENSG00000092094
Uniprot IDs		Q7Z699	Q9NPF4
PDB IDs		3SYX	6GWJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?