SPRED1

Description		sprouty related EVH1 domain containing 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Caveola Cytoplasmic Vesicle
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	MAPK Cascade Inactivation Of MAPK Activity Negative Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Phosphatase Activity Negative Regulation Of Angiogenesis Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Deacetylation
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Bipolar disorder ( 20351715) Birth weight ( 31043758) Cognitive performance (processing speed) ( 31598132) Crohn's disease ( 23128233) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Interacting Genes		11 interacting genes: CDKN1A DNAJB11 FAM118B KIT NAGK OSGEP PPP1CA RCC1 SUV39H1 TSC22D1 TTC19
Entrez ID		161742
HPRD ID		11601
Ensembl ID		ENSG00000166068
Uniprot IDs		Q7Z699
PDB IDs		3SYX
Enriched GO Terms of Interacting Partners?
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