DAXX and MYH11

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		DAXX	MYH11
Description		death domain associated protein	myosin heavy chain 11
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body PML Body	Cytosol Muscle Myosin Complex Myosin Filament Melanosome Extracellular Exosome
	Molecular Function	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding SUMO Binding Histone Binding Protein N-terminus Binding Androgen Receptor Binding	Motor Activity Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Actin Filament Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Apoptotic Process Activation Of JUN Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Positive Regulation Of Neuron Death Positive Regulation Of Nucleic Acid-templated Transcription Cellular Response To Sodium Arsenite	Muscle Contraction Smooth Muscle Contraction Skeletal Muscle Myosin Thick Filament Assembly Elastic Fiber Assembly Cardiac Muscle Fiber Development
Pathways		SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs			Tetrafluoroaluminate Ion
Diseases			Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Cognitive function ( 25644384) Coronary artery disease ( 29212778) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Pulse pressure ( 27841878 30578418) Resting heart rate ( 29769521 27798624) Serum uric acid levels in response to allopurinol in gout ( 25676789) Skin aging measurement ( 31522824) Waist-hip ratio ( 23966867)
Interacting Genes		91 interacting genes: ACVR2A AIRE AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CFLAR CREBBP CSNK2A1 DAPK3 DKC1 DMAP1 DNMT1 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 H3C3 H4-16 H4C6 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 MAP3K5 MCRS1 MDM2 MEN1 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RIPK3 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TCF3 TCF4 TCF7L2 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TSG101 UBC UBE2I USP7	4 interacting genes: APC DAXX GRB2 MAPKAPK5
Entrez ID		1616	4629
HPRD ID		04424	01174
Ensembl ID		ENSG00000204209	ENSG00000133392
Uniprot IDs		A0A024RCS3 B4E1C1 Q53F85 Q9UER7	A0A024QZJ4 A0A024QZJ6 P35749
PDB IDs		2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O
Enriched GO Terms of Interacting Partners?
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