TAMALIN and GABBR2

Number of citations of the paper that reports this interaction (PubMedID 11850456)
62

Data Source:
HPRD (two hybrid)

		TAMALIN	GABBR2
Description		trafficking regulator and scaffold protein tamalin	gamma-aminobutyric acid type B receptor subunit 2
Image
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Cell Junction Postsynaptic Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane GABA Receptor Complex
	Molecular Function	PDZ Domain Binding ADP-ribosylation Factor Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction Protein Localization Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission
Pathways			Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Baclofen Gabapentin gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil
Diseases
GWAS			High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		11 interacting genes: CYTH3 DLG4 DOCK1 FYN GABBR2 GRM1 GRM2 GRM3 GRM5 RPS6KA1 SRC	9 interacting genes: ATF4 ATF5 GABBR1 GLP1R HTR1A KCTD12 NSF SH3GL3 TAMALIN
Entrez ID		160622	9568
HPRD ID		17077	09552
Ensembl ID		ENSG00000161835	ENSG00000136928
Uniprot IDs		Q7Z6J2	H9NIL8 O75899
PDB IDs		2PNT	4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP
Enriched GO Terms of Interacting Partners?
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