CD55 and CR1

Number of citations of the paper that reports this interaction (PubMedID 11694537)
22

Data Source:
HPRD (in vitro)

		CD55	CR1
Description		CD55 molecule (Cromer blood group)	complement C3b/C4b receptor 1 (Knops blood group)
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cell Plasma Membrane Cell Surface Transport Vesicle Secretory Granule Membrane Anchored Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Lipid Binding	Virus Receptor Activity Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity
	Biological Process	ER To Golgi Vesicle-mediated Transport Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD4-positive, Alpha-beta T Cell Cytokine Production Neutrophil Degranulation Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Viral Entry Into Host Cell Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Complement Receptor Mediated Signaling Pathway Complement Activation, Classical Pathway Regulation Of Complement Activation Neutrophil Degranulation Innate Immune Response Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity
Pathways		Class B/2 (Secretin family receptors) Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade	Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade
Drugs		Chloramphenicol
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Blood protein levels ( 30072576 29875488 28240269) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Alzheimer's disease ( 21460840 19734903 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Systemic sclerosis ( 29293537)
Interacting Genes		6 interacting genes: ADGRE5 CD14 CR1 FYN GPLD1 LCK	6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4
Entrez ID		1604	1378
HPRD ID		00500	00398
Ensembl ID		ENSG00000196352	ENSG00000203710
Uniprot IDs		B1AP13 P08174	E9PDY4 P17927
PDB IDs		1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24 5FOA 6ILJ 6ILK	1GKG 1GKN 1GOP 1PPQ 2MCY 2MCZ 2Q7Z 5FO9
Enriched GO Terms of Interacting Partners?
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