CR1 and C4A

Number of citations of the paper that reports this interaction (PubMedID 8422437)
3

Data Source:
HPRD (in vitro)

		CR1	C4A
Description		complement C3b/C4b receptor 1 (Knops blood group)	complement C4A (Rodgers blood group)
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle
	Molecular Function	Virus Receptor Activity Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity	Complement Component C1q Binding Endopeptidase Inhibitor Activity
	Biological Process	Complement Receptor Mediated Signaling Pathway Complement Activation, Classical Pathway Regulation Of Complement Activation Neutrophil Degranulation Innate Immune Response Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade	Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade
Drugs			Immune Globulin Human
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus
GWAS		Alzheimer's disease ( 21460840 19734903 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Systemic sclerosis ( 29293537)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4	6 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3
Entrez ID		1378	720
HPRD ID		00398	00401
Ensembl ID		ENSG00000203710	ENSG00000244731
Uniprot IDs		E9PDY4 P17927	P0C0L4
PDB IDs		1GKG 1GKN 1GOP 1PPQ 2MCY 2MCZ 2Q7Z 5FO9	1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW
Enriched GO Terms of Interacting Partners?
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