CYLD and DDX58

Number of citations of the paper that reports this interaction (PubMedID 18636086)
126

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CYLD	DDX58
Description		CYLD lysine 63 deubiquitinase	DExD/H-box helicase 58
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GO Annotations	Cellular Component	Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Ruffle Membrane Ribonucleoprotein Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Lys63-specific Deubiquitinase Activity Proline-rich Region Binding Lys48-specific Deubiquitinase Activity	Double-stranded DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Binding Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Negative Regulation Of JNK Cascade Homeostasis Of Number Of Cells Regulation Of Inflammatory Response Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Necroptotic Process Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of NIK/NF-kappaB Signaling Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Positive Regulation Of Cellular Protein Localization Protein Linear Deubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Viral Process Protein Deubiquitination Regulation Of Cell Migration Negative Regulation Of Type I Interferon Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Regulation Of Type III Interferon Production Positive Regulation Of Interferon-beta Secretion Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases		Familial cylindromatosis Multiple familial trichoepithelioma Brooke-Spiegler syndrome
GWAS		Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 28067908 22412388) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 25642632 22019778) Lumbar spine bone mineral density ( 29499414 22504420)	Blood protein levels ( 30072576) Bone mineral density (spine) and age at menarche ( 26312577) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Inflammatory skin disease ( 25574825) Metabolite levels ( 23823483) Psoriasis ( 25903422 25574825 23143594) Psoriasis vulgaris ( 26626624) Red blood cell count ( 27863252)
Interacting Genes		22 interacting genes: AKT1 AURKB DDX58 DLG4 HDAC6 IKBKE IKBKG ITCH MAP3K7 MAPRE1 MIB2 PTPA TBK1 TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2S	14 interacting genes: CYLD MAVS PRKCG RNF122 RNF135 THAP12 TRIM40 UBC UBE2D1 UBE2D2 UBE2D3 UBE2K USP15 USP3
Entrez ID		1540	23586
HPRD ID		05427	13131
Ensembl ID		ENSG00000083799	ENSG00000107201
Uniprot IDs		A0A024R6T1 Q9NQC7	O95786
PDB IDs		1IXD 1WHL 1WHM 2VHF	2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG
Enriched GO Terms of Interacting Partners?
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