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DDX58
Description
DExD/H-box helicase 58
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Bicellular Tight Junction
Actin Cytoskeleton
Ruffle Membrane
Ribonucleoprotein Complex
Molecular Function
Double-stranded DNA Binding
RNA Helicase Activity
Double-stranded RNA Binding
Single-stranded RNA Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Biological Process
Positive Regulation Of Defense Response To Virus By Host
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Detection Of Virus
Response To Virus
Positive Regulation Of Gene Expression
Viral Process
Protein Deubiquitination
Regulation Of Cell Migration
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Regulation Of Type III Interferon Production
Positive Regulation Of Interferon-beta Secretion
Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus
RIG-I Signaling Pathway
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Defense Response To Virus
Positive Regulation Of Response To Cytokine Stimulus
Cellular Response To Exogenous DsRNA
Positive Regulation Of Interferon-alpha Secretion
Positive Regulation Of Tumor Necrosis Factor Secretion
Positive Regulation Of Interleukin-6 Secretion
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ub-specific processing proteases
Ovarian tumor domain proteases
OAS antiviral response
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Bone mineral density (spine) and age at menarche (
26312577
)
Hematocrit (
27863252
)
Hemoglobin concentration (
27863252
)
Inflammatory skin disease (
25574825
)
Metabolite levels (
23823483
)
Psoriasis (
25903422
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Red blood cell count (
27863252
)
Interacting Genes
14 interacting genes:
CYLD
MAVS
PRKCG
RNF122
RNF135
THAP12
TRIM40
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2K
USP15
USP3
Entrez ID
23586
HPRD ID
13131
Ensembl ID
ENSG00000107201
Uniprot IDs
O95786
PDB IDs
2LWD
2LWE
2QFB
2QFD
2RMJ
2YKG
3LRN
3LRR
3NCU
3OG8
3ZD6
3ZD7
4AY2
4BPB
4NQK
4ON9
4P4H
5E3H
5F98
5F9F
5F9H
6GPG
Enriched GO Terms of Interacting Partners
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