PLB1 and RIN3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		PLB1	RIN3
Description		phospholipase B1	Ras and Rab interactor 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane	Early Endosome Cytosol Cytoplasmic Vesicle
	Molecular Function	Phospholipase Activity Lysophospholipase Activity Phospholipase A2 Activity Retinyl-palmitate Esterase Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Retinoid Metabolic Process Phospholipid Metabolic Process Lipid Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Retinol Metabolic Process Positive Regulation Of Acrosome Reaction	Endocytosis Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Acyl chain remodelling of PC Retinoid metabolism and transport	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Excessive sweating ( 29895819) Heel bone mineral density ( 30598549) Intracranial aneurysm ( 29531279) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 25751625 29059683) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Dialysis-related mortality ( 21546767) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Granulocyte count ( 27863252) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Paget's disease ( 21623375) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 27863252)
Interacting Genes		5 interacting genes: NLGN3 PIK3R3 RIN3 S100A1 TNS2	41 interacting genes: ASB3 ASB8 BIN1 CRK CRKL CSRP3 CYP2C8 CYP46A1 DOK3 EPS8L2 EZH2 GATA1 GRAP2 ID2 KCTD17 LCK MPEG1 MT2A PLB1 POLR3F PSMD9 RAB5A RAB5B RAB5C RABAC1 RGS2 RTL8B SPATA12 SPRY4 SUV39H1 SYMPK TENT5A TGM1 TM4SF19 TNFAIP1 TSC1 TSSK3 ZBTB24 ZNF639 ZNF655 ZNF71
Entrez ID		151056	79890
HPRD ID		15141	11494
Ensembl ID		ENSG00000163803	ENSG00000100599
Uniprot IDs		B2RWP8 Q6P1J6	Q6NSK7 Q6ZRC2 Q86U22 Q8TB24
PDB IDs			3U23 4WCI
Enriched GO Terms of Interacting Partners?
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