ADRA2A and UCHL1

Number of citations of the paper that reports this interaction (PubMedID 19477270)
5

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		ADRA2A	UCHL1
Description		adrenoceptor alpha 2A	ubiquitin C-terminal hydrolase L1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Receptor Complex	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm
	Molecular Function	Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding
	Biological Process	Positive Regulation Of Cytokine Production Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction Cell-cell Signaling Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Receptor Transactivation Glucose Homeostasis Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Intestinal Absorption Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Negative Regulation Of Calcium Ion Transmembrane Transporter Activity	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Regulation Of Macroautophagy Protein Deubiquitination Sensory Perception Of Pain Axonal Transport Of Mitochondrion Cellular Response To Drug Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism	UCH proteinases
Drugs		Amphetamine Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Olanzapine Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Dipivefrin Prazosin Chlorpromazine Brimonidine Nortriptyline Amoxapine Amoxapine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Trimipramine Risperidone Epinastine Tolazoline Fenoldopam Dobutamine Pseudoephedrine Benzphetamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Carvedilol Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Mephentermine Yohimbine Methotrimeprazine 4-Methoxyamphetamine Methamphetamine Propericiazine Zuclopenthixol Dronedarone Lofexidine Epicept NP-1 Mianserin Asenapine Droxidopa Flupirtine Esmirtazapine Xylometazoline Levonordefrin Naphazoline Lurasidone Dosulepin Etoperidone Cirazoline Moxonidine Setiptiline Rilmenidine Tiapride	Phenethyl Isothiocyanate
Diseases			Parkinson's disease (PD)
GWAS		Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Homeostasis model assessment of beta-cell function ( 20081858) Longitudinal alcohol consumption ( 26081443) Platelet aggregation ( 20526338 29185836)	Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: ADRB1 EIF2B1 GGA3 GNAI1 GNAI2 GNAO1 GNB1 GNG2 GRK2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ	28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PLA2G2A PRKN RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28
Entrez ID		150	7345
HPRD ID		00078	01877
Ensembl ID		ENSG00000150594	ENSG00000154277
Uniprot IDs		P08913	P09936 V9HW74
PDB IDs		1HLL 1HO9 1HOD 1HOF	2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ
Enriched GO Terms of Interacting Partners?
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