CLDN19 and PKD2L1

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		CLDN19	PKD2L1
Description		claudin 19	polycystin 2 like 1, transient receptor potential cation channel
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Junction Complex Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Vesicle Calcium Channel Complex Intracellular Membrane-bounded Organelle Receptor Complex Ciliary Membrane Non-motile Cilium
	Molecular Function	Structural Molecule Activity Identical Protein Binding	Calcium Activated Cation Channel Activity Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Muscle Alpha-actinin Binding Alpha-actinin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Visual Perception Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Apical Junction Assembly Response To Stimulus Negative Regulation Of Wound Healing Tight Junction Organization Positive Regulation Of Cell Junction Assembly	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Cation Transport Smoothened Signaling Pathway Response To Water Sodium Ion Transmembrane Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Tight junction interactions
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Fatty acid desaturase activity (adipose tissue) ( 30453627) Glycerophospholipid levels ( 26068415) Heel bone mineral density ( 30598549 28869591) Macular thickness ( 30535121) Mean platelet volume ( 27863252) Obesity-related traits ( 23251661) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Phospholipid levels (plasma) ( 22359512) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum metabolite levels ( 24625756) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Squamous cell lung carcinoma ( 28604730) Vaccenic acid (18:1n-7) levels ( 28298293)
Interacting Genes		3 interacting genes: CREB3 PKD2L1 SRPK2	4 interacting genes: CLDN19 TNNI1 TNNI2 TNNI3
Entrez ID		149461	9033
HPRD ID		10834	16063
Ensembl ID		ENSG00000164007	ENSG00000107593
Uniprot IDs		Q8N6F1	Q1L4F0 Q9P0L9
PDB IDs			3TE3 4GIF 6DU8
Enriched GO Terms of Interacting Partners?
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