CD300LF and INPP5D

Number of citations of the paper that reports this interaction (PubMedID 15184070)
7

Data Source:
HPRD (in vitro)

		CD300LF	INPP5D
Description		CD300 molecule like family member f	inositol polyphosphate-5-phosphatase D
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytosol Cytoskeleton Plasma Membrane Membrane Raft
	Molecular Function	Phosphatidylserine Binding Interleukin-4 Receptor Binding Ceramide Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity SH3 Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Negative Regulation Of Mast Cell Activation Negative Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Interleukin-13-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Apoptotic Cell Clearance	Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Phosphatidylinositol Dephosphorylation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Leukocyte Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Lymphocyte counts ( 27863252) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neurological blood protein biomarker levels ( 31320639) Neutrophil count ( 27863252) Plateletcrit ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 22412388 23128233) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Family history of Alzheimer's disease ( 30617256) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		3 interacting genes: APP INPP5D PTPN6	42 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NLA PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17
Entrez ID		146722	3635
HPRD ID		17635	09033
Ensembl ID		ENSG00000186074	ENSG00000168918
Uniprot IDs		B4DQD2 J3KS52 Q8TDQ1	Q92835
PDB IDs		2NMS	2YSX 6IBD
Enriched GO Terms of Interacting Partners?
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