INPP5D and LILRB4

Number of citations of the paper that reports this interaction (PubMedID 9422771)
4

Data Source:
HPRD (in vitro)

		INPP5D	LILRB4
Description		inositol polyphosphate-5-phosphatase D	leukocyte immunoglobulin like receptor B4
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Membrane Raft	Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity SH3 Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	Antigen Binding Protein Binding Signaling Receptor Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Phosphatidylinositol Dephosphorylation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Leukocyte Migration	Adaptive Immune Response Signal Transduction Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 22412388 23128233) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Family history of Alzheimer's disease ( 30617256) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Sum eosinophil basophil counts ( 27863252)	Blood protein levels ( 28240269) Clozapine-induced agranulocytosis ( 25187353) Inflammatory bowel disease ( 23128233) Response to platinum-based chemotherapy (carboplatin) ( 21844884)
Interacting Genes		42 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NLA PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17	3 interacting genes: INPP5D PTPN11 PTPN6
Entrez ID		3635	11006
HPRD ID		09033	11996
Ensembl ID		ENSG00000168918	ENSG00000186818
Uniprot IDs		Q92835	A0A0A0MSZ8 Q8NHJ6
PDB IDs		2YSX 6IBD	3P2T 6K7O
Enriched GO Terms of Interacting Partners?
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