CSNK2B and CHRNA4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		CSNK2B	CHRNA4
Description		casein kinase 2 beta	cholinergic receptor nicotinic alpha 4 subunit
Image
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Protein Kinase CK2 Complex Nuclear Matrix PcG Protein Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Cell Junction Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Dopaminergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Transcription Factor Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding
	Biological Process	Protein Folding Phosphatidylcholine Biosynthetic Process Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Wnt Signaling Pathway Macroautophagy Peptidyl-threonine Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Response To Testosterone Cellular Protein-containing Complex Assembly Neutrophil Degranulation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Kinase Activity Regulation Of DNA Binding Endothelial Tube Morphogenesis Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Respiratory Gaseous Exchange Locomotory Behavior Regulation Of Dopamine Secretion Sensory Perception Of Pain Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Exploration Behavior B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		ATP Quercetin	Nicotine Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Dextromethorphan Carbamazepine Atropine Thiopental Mecamylamine Galantamine Scopolamine Estradiol Primidone Methylphenobarbital Ethanol Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Pozanicline RPI-78M Epibatidine Cytisine
Diseases			Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 26316170) Ulcerative colitis ( 28067908)	Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 28972577 26440539) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		204 interacting genes: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BCCIP BHLHE41 BID BMI1 BRCA1 BTF3 C6orf136 CACNA1A CALM1 CBX4 CCDC115 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CENPB CHEK1 CHRNA4 CIC CIP2A CIPC CLOCK COIL COL4A2 COPS3 COPS7A CPNE7 CRISP2 CSN1S1 CSN2 CSNK1E CSNK2A1 CSNK2A2 CTDP1 CTNNB1 DACT1 DALRD3 DELEC1 DENND5A DNMT1 DPF3 EIF2S2 EIF5 EIF6 EPS8 ERCC8 ESR1 FAF1 FBXL15 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 GADD45GIP1 GAMT GBP2 GLB1 GNB5 GRK2 GSK3B GTPBP2 HEXB HIRIP3 HNRNPA2B1 HOXB6 HTRA1 IER3IP1 INTS11 IRS1 ITSN1 KCNA3 KDM6B KIF2C LCK LEPR LMO4 LRP5L LYN LYST MAPK14 MBD4 MDM2 MME MOXD1 MPP2 NAP1L1 NCF1 NMT2 NOLC1 NOTCH3 NPAS2 NRBP1 ODC1 OGA OGT PDS5A PER1 PER2 PFKFB4 PHC2 PHF11 PHRF1 PIN1 PITPNA PLXNA3 POT1 PPID PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PYROXD2 RAD51 RFC1 RNF126 RNF7 RORB RPA1 RPL13 RPL41 RPL5 RPS6KA5 RPS6KB1 RPS6KB2 RRAD RXRA SARNP SDHA SEC11A SHANK3 SHMT1 SHMT2 SIMC1 SIRT1 SNX2 SPOUT1 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TCTEX1D2 TFAP2A TLE1 TNFAIP1 TOP2B TP53 TP53BP2 TP63 TRIM27 TSEN54 TUBB2B UBE2I UPF1 USO1 UTP14A VDAC1 VRK3 WDR1 WDR18 WFIKKN1 ZFP36L1 ZNF44 ZNF71 ZNF76 ZNF784 ZNHIT1	8 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RHOU UBQLN1 VSNL1 YWHAH
Entrez ID		1460	1137
HPRD ID		00278	00333
Ensembl ID		ENSG00000204435	ENSG00000101204
Uniprot IDs		A0A1U9X7J2 N0E4C7 P67870	B4DK78 P43681 Q4VAQ3 Q59FV0
PDB IDs		1DS5 1JWH 1QF8 3EED 4DGL 4MD7 4MD8 4MD9 4NH1 6Q38	2GVT 2LLY 5KXI 6CNJ 6CNK
Enriched GO Terms of Interacting Partners?
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