CHRNA4 and CHRNB2

Number of citations of the paper that reports this interaction (PubMedID 15944128)
116

Data Source:
HPRD (in vivo)

		CHRNA4	CHRNB2
Description		cholinergic receptor nicotinic alpha 4 subunit	cholinergic receptor nicotinic beta 2 subunit
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Cell Junction Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Dopaminergic Synapse Integral Component Of Presynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Integral Component Of Membrane Cell Junction Neuron Projection Plasma Membrane Raft Synapse Dopaminergic Synapse Cholinergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding Protein-containing Complex Binding
	Biological Process	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Respiratory Gaseous Exchange Locomotory Behavior Regulation Of Dopamine Secretion Sensory Perception Of Pain Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Exploration Behavior B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	Action Potential Conditioned Taste Aversion Response To Hypoxia Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Membrane Potential Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Nervous System Process Cognition Membrane Depolarization Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine Regulation Of Synaptic Vesicle Exocytosis
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Dextromethorphan Carbamazepine Atropine Thiopental Mecamylamine Galantamine Scopolamine Estradiol Primidone Methylphenobarbital Ethanol Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Pozanicline RPI-78M Epibatidine Cytisine	Nicotine Dextromethorphan Carbamazepine Atropine Mecamylamine Galantamine Scopolamine Ethanol Physostigmine Decamethonium Varenicline Pozanicline RPI-78M Rivanicline Epibatidine Cytisine
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)	Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 28972577 26440539) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking status (heavy vs never) ( 26423011)	Nicotine dependence ( 28440896) Smoking behaviour (cigarettes smoked per day) ( 30679032)
Interacting Genes		8 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RHOU UBQLN1 VSNL1 YWHAH	3 interacting genes: CHRNA2 CHRNA4 CRELD2
Entrez ID		1137	1141
HPRD ID		00333	00335
Ensembl ID		ENSG00000101204	ENSG00000160716
Uniprot IDs		B4DK78 P43681 Q4VAQ3 Q59FV0	P17787 Q5SXY3
PDB IDs		2GVT 2LLY 5KXI 6CNJ 6CNK	2GVT 2K58 2K59 2KSR 2LM2 5KXI 6CNJ 6CNK
Enriched GO Terms of Interacting Partners?
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