CSF3 and CSF3R

Number of citations of the paper that reports this interaction (PubMedID 10364174)
5

Data Source:
HPRD (in vivo)

		CSF3	CSF3R
Description		colony stimulating factor 3	colony stimulating factor 3 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Activity Granulocyte Colony-stimulating Factor Receptor Binding Growth Factor Activity Enzyme Binding	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding
	Biological Process	Immune Response Multicellular Organism Development Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Granulocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Response To Ethanol Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Actin Cytoskeleton Reorganization	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis
Pathways		Other interleukin signaling Interleukin-10 signaling	Other interleukin signaling Transcriptional regulation of granulopoiesis
Drugs			Pegfilgrastim Filgrastim FavId Lenograstim
Diseases
GWAS		Asthma ( 31619474) Bipolar disorder ( 31043756) Composite immunoglobulin trait (IgA x IgG) ( 28628107) Creatine kinase levels ( 29403010) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mitochondrial DNA copy number ( 30704525) Myeloid white cell count ( 27863252) Neutrophil count ( 25096241 20172861 27863252) Neutrophil percentage of white cells ( 27863252) Rheumatoid arthritis ( 30423114 24390342) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 20139978 27863252 21738480 28158719) White blood cell count (neutrophil) ( 28158719) White blood cell types ( 21738478)	Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Lymphocyte percentage of white cells ( 27863252) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 27863252)
Interacting Genes		2 interacting genes: CSF3R ELANE	19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2
Entrez ID		1440	1441
HPRD ID		00736	00737
Ensembl ID		ENSG00000108342	ENSG00000119535
Uniprot IDs		P09919 Q6FH65 Q8N4W3	Q99062
PDB IDs		1CD9 1GNC 1PGR 1RHG 2D9Q 5GW9 5ZO6	1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?