C4A and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 11773063)
60

Data Source:
HPRD (in vitro)

		C4A	C5AR2
Description		complement C4A (Rodgers blood group)	complement component 5a receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle	Cell Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Complement Component C1q Binding Endopeptidase Inhibitor Activity	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Interleukin-6 Secretion Regulation Of Interleukin-8 Secretion
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs		Immune Globulin Human
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		6 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3	3 interacting genes: C3 C4A C5AR1
Entrez ID		720	27202
HPRD ID		00401	17072
Ensembl ID		ENSG00000244731	ENSG00000134830
Uniprot IDs		P0C0L4	Q9P296
PDB IDs		1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW
Enriched GO Terms of Interacting Partners?
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