ADORA2B and EZR

Number of citations of the paper that reports this interaction (PubMedID 12080047)
36

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		ADORA2B	EZR
Description		adenosine A2b receptor	ezrin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Fibrillar Center Ruffle Immunological Synapse Uropod Extracellular Space Cell Cytoplasm Endosome Cytosol Actin Filament Plasma Membrane Microvillus Brush Border Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Protein-containing Complex Ciliary Basal Body Cell Projection Cell Body Microspike Plasma Membrane Raft Apical Part Of Cell Perinuclear Region Of Cytoplasm Cell Tip Extracellular Exosome Invadopodium Cell Periphery Astrocyte Projection Schwann Cell Microvillus Cytoplasmic Side Of Apical Plasma Membrane
	Molecular Function	G Protein-coupled Adenosine Receptor Activity Protein Binding	RNA Binding Actin Binding Protein Binding Microtubule Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding Protein Kinase A Binding ATPase Binding Disordered Domain Specific Binding
	Biological Process	Activation Of MAPK Activity Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Extracellular Stimulus Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Degranulation Cellular Protein Metabolic Process Relaxation Of Vascular Smooth Muscle Regulation Of Synaptic Vesicle Exocytosis	Negative Regulation Of Transcription By RNA Polymerase II Intestinal D-glucose Absorption Sphingosine-1-phosphate Receptor Signaling Pathway Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Protein Kinase A Signaling Gland Morphogenesis Membrane To Membrane Docking Microvillus Assembly Astral Microtubule Organization Actin Cytoskeleton Reorganization Receptor Internalization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Cellular Protein-containing Complex Localization Positive Regulation Of Multicellular Organism Growth Cortical Microtubule Organization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Secretion Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Establishment Of Centrosome Localization Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Protein Localization To Cell Cortex Negative Regulation Of Interleukin-2 Secretion Regulation Of NIK/NF-kappaB Signaling Regulation Of Organelle Assembly Terminal Web Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of P38MAPK Cascade Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1
Drugs		Theophylline Adenosine Enprofylline Defibrotide
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Bladder cancer (smoking interaction) ( 24662972) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Hair color ( 29662168)
Interacting Genes		7 interacting genes: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267	51 interacting genes: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MME MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 VPS11 WFDC1 WWOX
Entrez ID		136	7430
HPRD ID		15971	00475
Ensembl ID		ENSG00000170425	ENSG00000092820
Uniprot IDs		P29275	P15311
PDB IDs			1NI2 4RM8 4RM9 4RMA
Enriched GO Terms of Interacting Partners?
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