KLF6 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KLF6	POLA2
Description		Kruppel like factor 6	DNA polymerase alpha 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Intracellular Membrane-bounded Organelle	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS		Asthma (bronchodilator response) ( 23508266) Coronary artery calcification ( 23870195) Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549 28869591) Multiple sclerosis ( 31604244) Plasma anti-thyroglobulin levels ( 29678681)	Acne (severe) ( 24927181)
Interacting Genes		16 interacting genes: APOM APP CELSR2 EHMT2 FBL GTF3C1 HDAC3 KLF4 LCOR NOP56 NUFIP1 PNO1 POLA2 SP1 TAF9 TP53	41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2
Entrez ID		1316	23649
HPRD ID		03632	10160
Ensembl ID		ENSG00000067082	ENSG00000014138
Uniprot IDs		D3GC14 Q99612	Q14181
PDB IDs			2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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