UBR3 and UBE2A

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		UBR3	UBE2A
Description		ubiquitin protein ligase E3 component n-recognin 3	ubiquitin conjugating enzyme E2 A
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Integral Component Of Membrane	Chromatin Nuclear Chromatin XY Body Nucleoplasm Cytosol HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	In Utero Embryonic Development Suckling Behavior Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Smell Embryo Development Ending In Birth Or Egg Hatching Protein Ubiquitination Olfactory Behavior Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Protein Polyubiquitination Blastocyst Hatching DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Proliferation Response To UV Protein Ubiquitination Histone Ubiquitination Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Longitudinal change in brain amyloid plaque burden ( 26268530) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Urate levels in obese individuals ( 25811787)	Brain connectivity ( 23471985)
Interacting Genes		7 interacting genes: APEX1 DZIP3 MAGEC2 UBE2A UBE2B UBE2D2 UBE2H	26 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 HLTF KCMF1 MDM2 PCNA PRKN RAD18 RC3H1 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2
Entrez ID		130507	7319
HPRD ID		15887	02422
Ensembl ID		ENSG00000144357	ENSG00000077721
Uniprot IDs		Q6ZT12	A0A0D9SG71 P49459
PDB IDs			6CYO 6CYR
Enriched GO Terms of Interacting Partners?
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