COL8A2 and SGTA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		COL8A2	SGTA
Description		collagen type VIII alpha 2 chain	small glutamine rich tetratricopeptide repeat containing alpha
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Nucleus Cytoplasm Cytosol Membrane TRC Complex Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein Binding, Bridging	Protein Binding Identical Protein Binding Protein Self-association Molecular Adaptor Activity BAT3 Complex Binding
	Biological Process	Angiogenesis Extracellular Matrix Organization Camera-type Eye Morphogenesis Epithelial Cell Proliferation Cell-cell Adhesion	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Viral Process Ubiquitin-dependent ERAD Pathway Chaperone-mediated Protein Folding Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Folding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Posterior polymorphous corneal dystrophy (PPCD) Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy
GWAS		Central corneal thickness ( 29760442) Corneal structure ( 23291589) Early spontaneous preterm birth ( 31194736) Intraocular pressure ( 29617998 29785010 31959993)
Interacting Genes		3 interacting genes: COL8A1 LMNA SGTA	98 interacting genes: ADIPOQ ADRM1 AGR3 BAG6 BCL2L12 BTC C1QA C1QTNF1 C1QTNF6 C3orf52 CD79B CD99 CD99L2 CDH15 COL1A2 COL8A2 CSF1 CST1 CTSL CXCL8 EFEMP1 EFEMP2 ERP27 EVA1B F11R FERD3L FIP1L1 FKBP7 FXYD7 GABARAPL2 GAL GHR GIP GPX7 GRN GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 HSPA8 IGL IGLC1 IRF3 IRF5 ITPRIPL1 KASH5 KRT6A KTN1 LAIR2 LAT MSMB MSTN MYDGF NAXD NME3 NR3C1 NXF1 PBXIP1 PCDHA4 PFN2 PGR PIAS1 PLAAT4 PPIB PPIC PPP1R3C PRAP1 PTN RPN1 SDC4 SERPINE1 SGCA SLPI SMAGP SOD3 SPP1 SPPL2A SRGN SYT11 SYT4 TFF3 TFRC TGFA TMEM174 TMEM31 TMPO TMUB2 TNFRSF13B TNFRSF1A TWSG1 TXNDC12 UBL4A UPK3A VIP WBP1L ZG16 ZG16B
Entrez ID		1296	6449
HPRD ID		08347	04568
Ensembl ID		ENSG00000171812	ENSG00000104969
Uniprot IDs		E9PP49 P25067	O43765
PDB IDs			2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?
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